50 percent of the US population lives within 600 miles of Nashville. Interstate highways lead into Nashville from all directions, providing excellent access by automobile. I-65 connects the city with Louisville, Indianapolis and Chicago to the north and Birmingham, Montgomery and Mobile to the south. Nashville is bisected by I-40, an east-west freeway that also passes through cities such as Asheville, Knoxville, Memphis, Little Rock and Oklahoma City.

I-24 crosses the city from the northwest to the southeast, providing convenient travel from St. Louis, Chattanooga and Atlanta. All of the interstates converge in a large circle around downtown Nashville. Access to suburban areas is made easier by I-440 and I-265. Construction is under way on SR-840, a loop around the outer edges of Davidson County.